Endocrine Abstracts

Introduction: In Romania, the prevalence of postmenopausal osteoporosis in urban centers was estimated by a study in 2007 to be 16.5%. Using alendronate we are increasing bone mineral density and reducing bone turn-over in women with postmenopausal osteoporosis.Materials and methods: There were examined 55 postmenopausal women with osteoporosis (average age 62±4.5 years). Bone mineral density (BMD) was determined by dual-energy X-ray absorptiometer ...

Aim: To evaluate the effect of risedronate vs ibandronate in treatment of systemic osteoporosis in postmenopausal women.Materials and methods: We examined 57 postmenopausal women with systemic osteoporosis (average age 61±3.5 years). Bone mineral density (BMD) was determined by dual-energy X-ray absorptiometer (HOLOGIC Delphi W; SN 7044909) on lumbar spine. Examination was performed before the onset of treatment and after a period of 1, 2 and 3 year...

Introduction: Thyroid tissue may be found anywhere along the course of thyroglossal duct. Sublingual thyroid is a rare type of ectopic thyroid tissue resulting from failure of the embryonic development and migration of the thyroid gland to its normal pre-laryngeal site, reaching between genio-hioid and mylohyiod muscles. In most cases, hypothyroidism develops due to inadequate hormon production. Hypothyroidism may produce pituitary enlargement secondary to thyrotroph hyperplas...

Introduction: Acromegaly is a rare, challenging disease that if not appropriately treated can lead to numerous complications. Some of the most frequent complications are cardiovascular (hypertension, secondary cardiomyopathy, arrhythmias, valvulopathies, heart failure) and metabolic (secondary diabetes, various alterations of the lipid metabolisms). Aim: The aim is to asses the impact of long-term acromegaly on the cardiovascular system and glucide and l...

Introduction: Kabuki syndrome (KS) is a rare congenital, multisystemic disorder caused by pathogenic variants of KMT2D or KDM6A genes, causing autosomal dominant KS type 1 (more than 80%) and X-linked KS type 2 respectively. The phenotype spectrum is highly variable, consisting of a mixture of any of the five cardinal features (facial dysmorphic features, skeletal defects, dermatoglyphic abnormalities, various degrees of intellectual and growth retardation) with structural dis...

Adipose tissue performs an important endocrine role, mediated by hormones (adipocytokines) which are specifically secreted by the adipocytes. Epidemiological data consistently show an association between weight gain and the risk of colorectal cancer in adults.This observation led to the evaluation of a possible linking role of adipocytokines with cancer pathogenesis. There are several studies that associate adipocytokines with colorectal malignancy, but few data about patients...

Abnormalities of growth are one of the most common reasons for the paediatric–endocrinology consults. It’s an obvious manifestation with countless possible causes behind, and sometimes we can have unexpected diagnosis.Case presentation: we investigated the case of a 4 years old girl, born at term, naturally, SGA: birth weight=1950 g, who presented in the Endocrinology Department for short stature. Clinical evaluation: 89.5 cm (−4 DS), 11 ...

Objective: There are a few studies regarding the relationship between psoriasis and polycystic ovary syndrome (PCOS).The aim of present study was to identify the prevalence of PCOS in patients with psoriasis.Material and methods: A retrospective study has been performed upon 1236 patients diagnosed with psoriasis (male 54.13%, female 45.87%) during 2004–2011. The prevalence of polycystic ovary syndrome (PCOS) has been quantifi...

Introduction: The most common cause of Cushing’s disease is ACTH secreting tumours of the pituitary gland. It is associated with high morbidity and mortality. Pasireotide, a potential therapy, has a unique, broad somatostatin-receptor–binding profile, with high binding affinity for somatostatin-receptor subtype 5.Case report: We present the a 40-years-old man diagnosed in 2005 with Cushing’s Disease for which a left adrenalectomy was perfo...

Introduction: Anaplastic thyroid carcinoma are highly aggressive solid tumors, with a median survival of less than 6 months after diagnosis. They typically occur in patients who are 65 years of age or older. On the other hand, papillary thyroid carcinoma and follicular thyroid carcinoma are generally indolent, with very few progressive cases.Case report: A 64-year-old patient with no significant pathological history, known with goiter for about 40 years ...